Much of the real work of the Chamber occurs at the committee level and many of AmCham's successes in lobbying for an improved business environment can be traced to them. AmCham Taipei is comprised of 24 committees that represent and promote the specific interests of their fields of business. Each industry committee creates a Priority Issues Paper included in the annual Taiwan White Paper, which is presented to the government and the public as a summary of the current business climate in Taiwan for each specific field. AmCham Taipei also includes several Special Committees that organize and host professional, social and recreational services for members and for the Taipei community at large. Major events overseen by these committees include the annual American Ball, Hsieh Nien Fan, July 4th Celebration, Best Ad Night and Executive Insight Presentations.

許多會務工作是透過委員會會議完成的，許多商會順利推動的經貿環境改善措施，其實也歸功於委員會的貢獻。商會現在共有24個委員會，分別代表並強化他們所在的領域環境。每一個委員會都會製作自己的優先議題報告並刊登在年度的《台灣白皮書》中；而白皮書所反映給政府跟一般讀者的，就是台灣各個領域經營環境的總結報告。商會同時也有一些特別委員會，負責規劃社交及休閒活動，這些活動開放給會員及大台北地區的居民。由這些委員會負責的大型活動包括了年度的「年度舞會」、「謝年飯」、「美國獨立紀念日慶祝活動」、「最佳廣告之夜」。